Genshiro A, Sunagawa, M.D.,Ph.D.

Associate Professor, Division of Developmental Biology (Cooperative Division)

Research Interests

   Our goal is the clinical application of active hypometabolism. We aim to provide effective and meaningful treatment for issues in modern medicine that stem from a high basal metabolic rate of human or human tissues. We believe synthetic hibernation for human can drastically improve medical transportation, tissue preservation, and the safety of general anesthesia. Moreover, if human lifespan can be safely extended by synthetic hibernation, traveling to the future or to deep space would not be a fiction anymore. The spaciotemporal cognitive function of human will change totally. Toward human hibernation, we will especially focus on discovering the mechanism of natural hibernation and torpor.

Research Focus

R&D of synthetic hibernation for humans.

Recent Publication

• Suita K, Ishikawa K, Kaneko M, Wataki A, Takahashi M, Kiyonari H,Sunagawa GA*. (2023)
  Mouse embryonic stem cells embody organismal-level cold resistance.
  Cell Rep. 112954.
• Kyo S, Murata K, Kawatou M, Minatoya K,Sunagawa GA*, Masumoto H*. (2022)
  Quiescence-inducing neurons-induced hypometabolism ameliorates acute kidney injury in a mouse model mimicking cardiovascular surgery requiring circulatory arrest.
  JTCVS Open doi: 10.1016/j.xjon.2022.11.001.
• Takahashi TM, Sunagawa GA*, Soya S, Abe M, Sakurai K, Ishikawa K, Yanagisawa M, Hama H, Hasegawa E, Miyawaki A, Sakimura K, Takahashi M, Sakurai T*. (2020)
  A Discrete Neuronal Circuit that induces Hibernation-like State in Rodents
  Nature ,583, 109–114.

Contact

Office: Laboratory for Hibernation Biology, RIKEN Center for Biosystems Dynamics Research

Address: 2-2-3 Minatojima-Minamimachi, Chuo-ku, Kobe, Japan, 650-0047

Tel: +81-78-306-3302

E-mail: lhb_info@ml.riken.jps

Webpage:
https://www.bdr.riken.jp/en/research/labs/sunagawa-g/index.html

https://www.riken.jp/en/research/labs/bdr/hibernate_biol/index.html