Shigeo Hayashi, Ph.D.

Professor, Division of Developmental Biology (Cooperative Division)

Research Interests

   Key challenge in developmental biology is to understand the mechanism of specie-specific pattern formation. Genome encoded blue print of body patterning instructs cells to build precisely patterned organs. We study the question of how cell shape is specified, and how uniquely shaped cells build organs. We use powerful genetics and imaging systems of < em>Drosophila to investigate the role of intracellular skeletons and trafficking in cell shape formation and higher order tissue patterning, with emphasis in uncovering the mechanical basis of morphogenesis.

Research Focus

Mechanism of epithelial morphogenesis in Drosophila

Recent Publication

• Dong B, Kakihara K, Otani T, Wada H, Hayashi S. (2013)
  Rab9 and retromer regulate retrograde trafficking of luminal protein required for epithelial tube length control.
  Nature Communications 4, 1358.
• Kondo T. and Hayashi S. (2013)
  Mitotic cell rounding accelerates epithelial invagination.
  Nature 494, 125-129.
• Otani T, Oshima K, Onishi S, Takeda M, Shinmyozu K, Yonemura S, Hayashi S. (2011)
  IKKε Regulates Cell Elongation through Recycling Endosome Shuttling.
  Developmental Cell 20, 219-232.
• Tajiri R, Misaki K, Yonemura S, Hayashi S. (2010)
  Dynamic shape changes of ECM-producing cells drive morphogenesis of ball-and-socket joints in the fly leg.
  Development 137, 2055-2063.
• Kawahashi K, Hayashi S. (2010)
  Dynamic intracellular distribution of Notch during activation and asymmetric cell division revealed by functional fluorescent fusion proteins.
  Genes to Cells 15, 749-759.
• Niwa N, Akimoto-Kato A, Niimi T, Tojo K, Machida R, Hayashi S. (2010)
  Evolutionary origin of the insect wing via integration of two developmental modules.
  Evolution & Development 12, 168-176.

Contact

Office: Laboratory for Morphogenetic Signaling, Center for Biosystems Dynamics Research, RIKEN

Address: 2-2-3 Minatojima-Minamimachi, Chuo-ku, Kobe, Japan, 650-0047

Tel: 81-78-306-3185

FAX: 81-78-306-3183

E-mail: shigeo.hayashi@riken.jp

Webpage: https://signaling.riken.jp/