Hiroshi Sakamoto, Ph.D.

Professor, Division of Biosignal Transduction, Gene Expression

Research Focus

Biological Functions of RNA-binding Proteins and Chromatin-associated Factors

Recent Publications

  • Miwa, T., Ohtani, K., Inoue, K., Sakamoto, H. (2022)
    The germ cell-specific TAP-like protein NXF-2 forms a novel granular structure and is required for tra-2 3'UTR-dependent mRNA export in Caenorhabditis elegans.
    Genes to Cells 27, 621-628.
  • Miwa, T., Inoue, K., & Sakamoto, H. (2019)
    MRG-1 is required for both chromatin-based transcriptional silencing and genomic integrity of primordial germ cells in C. elegans.
    Genes to Cells 24, 377-389.
  • Miwa, T., Takasaki, T., Inoue, K., & Sakamoto, H. (2015)
    Restricted distribution of mrg-1 mRNA in C. elegans primordial germ cells through germ granule-independent regulation.
    Genes to Cells 20, 932-942.
  • Shiimori, M., Inoue, K. & Sakamoto, H. (2013)
    A specific set of EJC subunits is required for the nuclear retention of unspliced RNAs in C. elegans.
    Mol. Cell. Biol. 33, 444-456.
  • Fujiwara,T., Fukao, A., Sasano, Y., Matsuzaki, H., Kikkawa, U., Imataka, A., Inoue, K., Endo, S., Sonenberg, N. Thoma, C. & Sakamoto, H. (2012)
    Functional and direct interaction between the RNA binding protein HuD and active Akt1.
    Nucleic Acids Res. 40, 1944-1953.
  • Fukao, A., Sasano, Y., Imataka, H., Inoue, K., Sakamoto, H., Sonenberg, N., Thoma, C & Fujiwara, T. (2009)
    The ELAV protein HuD stimulates cap-dependent translation in a poly(A)- and eIF4A-dependent manner.
    Mol. Cell 36, 1007-1017. (see also Preview by Chen & Shyu in Mol. Cell Dec. 24)
  • Takasaki, T., Liu, Z., Habara, Y., Nishiwaki, K., Nakayama, J., Inoue, K., Sakamoto, H. & Strome, S. (2007)
    MRG-1, an autosome-associated protein, silences X-linked genes and protects germline immortality in Caenorhabditis elegans.
    Development 134, 757-767. (see also In This Issue in Development Feb. 15)

Contact (H. Sakamoto)

Office: Grad. Sch. Sci. Tech. Bldg 1, Room 404

Tel: +81-78-803-5796

FAX: +81-78-803-5720

E-mail: hsaka@kobe-u.ac.jp

URL: http://www.research.kobe-u.ac.jp/fsci-rna/