准教授:近藤 侑貴(こんどう ゆうき)

学位:博士(理学)

担当授業科目

(学部)Introduction to Biology、生物学演習I、生物学実験IB、生物学実験IIIABC、生化学基礎I、植物環境適応論I,II
(大学院)特別講義「構成生物学」、先端融合科学特論B、生体分子機構概論II
(全学共通教育) 生物学A

研究の興味

 生き物の体は、多様な細胞から成り立っています。そこには、まるで人間の社会のように様々な機能に特化した細胞が秩序立って存在し、それぞれがコミュニケーションをとりながら個体を維持しています。細胞がどうやって自らの運命を決めていくのかは、まだ解明されていない部分も多く、生物発生学の非常に興味深いトピックの1つです。とりわけ植物の細胞は、挿し木や接ぎ木に代表されるように、かなり自在に運命を変えることができます。このような植物細胞の柔軟かつ堅固な運命決定機構にせまるため、維管束を構成する多様な細胞に着目をしています。私たちの研究室で新規に開発した維管束細胞の分化誘導系「VISUAL」という手法をベースに、分子生物学・遺伝学・情報生物学・1細胞解析など最新の手法を取り入れ、構成生物学的な観点から研究を展開しています。

主な研究テーマ

・維管束分化誘導系VISUALを用いた細胞運命決定機構の研究
・得られた知見を基にした維管束細胞の人為的誘導や運命操作への挑戦
・モデル植物を用いた幹細胞制御ネットワークの進化的研究

最近の代表的な論文

  • Hanano S, Tomatsu H, Ohnishi A, Kobayashi K, Kondo Y, Betsuyaku S, Takita E, Ogata Y, Ozawa K, Suda K, Hosouchi T, Nagase T, Suzuki H, Sakurai N, Masumoto H, Fukuda H, Shibata D. (2020)
    An Artificial Conversion of Roots into Organs with Shoot Stem Characteristics by Inducing Two Transcription Factors
    iScience 23, Article number: 101332.
  • Tamaki T, Oya S, Naito M, Ozawa Y, Furuya T, Saito M, Sato M, Wakazaki M, Toyooka K, Fukuda H, Helariutta Y, Kondo Y. (2020)
    VISUAL-CC system uncovers the role of GSK3 as an orchestrator of vascular cell type ratio in plants.
    Comms Biol. 3, Article number: 184. [大学プレスリリース]
  • Nurani, A.M., Ozawa, Y., Furuya, T., Sakamoto, Y., Ebine, K., Matsunaga, S., Ueda, T., Fukuda, H. and Kondo, Y. (2020)
    Deep Imaging Analysis in VISUAL Reveals the Role of YABBY Genes in Vascular Stem Cell Fate Determination.
    Plant and Cell Physiology, 61, 255-264. [関連記事]
  • Toyokura, K., Goh, T., Shinohara, H., Shinoda, A., Kondo, Y., Okamoto, Y., Uehara, T., Fujimoto, K., Okushima, Y., Ikeyama, Y., Nakajima, K., Mimura, T., Tasaka, M., Matsubayashi, Y. and Fukaki, H. (2019)
    Lateral inhibition by a peptide hormone-receptor cascade during Arabidopsis lateral root founder cell formation.
    Developmental Cell, 48, 64-75.
  • Miyashima, S., Roszak, P., Sevilem, I., Toyokura, K., Blob, B., Heo, J.O., Mellor, N., Help-Rinta-Rahko, H., Otero, S., Smet, W., Boekschoten, M., Hooiveld, G., Hashimoto, K., Smetana, O., Siligato, R., Wallner, E.S., Mähönen, A.P., Kondo, Y., Melnyk, C.W., Greb, T., Nakajima, K., Sozzani, R., Bishopp, A., De, Rybel, B. and Helariutta, Y. (2019)
    Mobile PEAR transcription factors integrate positional cues to prime cambial growth.
    Nature, 565, 490-494.
  • Yamazaki, K., Kondo, Y., Kojima, M., Takebayashi, Y., Sakakibara, H. and Fukuda, H. (2018)
    Suppression of DELLA signaling induces procambial cell formation in culture.
    The Plant journal, 94, 48-59.
  • Takahashi, F., Suzuki, T., Osakabe, Y., Betsuyaku, S., Kondo, Y., Dohmae, N., Fukuda, H., Yamaguchi-Shinozaki, K. and Shinozaki, K. (2018)
    A small peptide modulates stomatal control via abscisic acid in long-distance signalling.
    Nature, 556, 235-238.
  • Saito, M., Kondo, Y. and Fukuda, H. (2018)
    BES1 and BZR1 Redundantly Promote Phloem and Xylem Differentiation.
    Plant and Cell Physiology, 59, 590-600.
  • Guo, X., Wang, J., Gardner, M., Fukuda, H., Kondo, Y., Etchells, J.P., Wang, X. and Mitchum, M.G. (2017)
    Identification of cyst nematode B-type CLE peptides and modulation of the vascular stem cell pathway for feeding cell formation.
    PLoS pathogens, 13, e100614.
  • Morita, J., Kato, K., Nakane, T., Kondo, Y., Fukuda, H., Nishimasu, H., Ishitani, R. and Nureki, O. (2016)
    Crystal structure of the plant receptor-like kinase TDR in complex with the TDIF peptide.
    Nature Communications, 7, 12383.
  • Kondo, Y., Nurani, A.M., Saito, C., Ichihashi, Y., Saito, M., Yamazaki, K., Mitsuda, N., Ohme-Takagi, M. and Fukuda, H. (2016)
    Vascular Cell Induction Culture System Using Arabidopsis Leaves (VISUAL) Reveals the Sequential Differentiation of Sieve Element-Like Cells.
    The Plant cell, 28, 1250-1262. [関連記事]
  • Kondo, Y., Fujita, T., Sugiyama, M. and Fukuda, H. (2015)
    A novel system for xylem cell differentiation in Arabidopsis thaliana.
    Molecular plant, 8, 612-621.
  • Kondo, Y., Ito, T., Nakagami, H., Hirakawa, Y., Saito, M., Tamaki, T., Shirasu, K. and Fukuda, H. (2014)
    Plant GSK3 proteins regulate xylem cell differentiation downstream of TDIF-TDR signalling.
    Nature Communications, 5, 3504.

(総説、著書)

  • Saito, M. and Kondo, Y. (2019)
    What Can Cell Culture Systems Reveal About Sieve Element Differentiation?
    Methods in molecular biology, 2014, 459-466.
  • Kondo, Y. (2018)
    Reconstitutive approach for investigating plant vascular development.
    Journal of plant research, 131, 23-29.
  • Kondo, Y. and Sugano, S.S. (2018)
    Opening new avenues for plant developmental research.
    Journal of plant research, 131, 3-4.
  • Nurani, A.M., Kondo, Y. and Fukuda, H. (2018)
    Ectopic Vascular Induction in Arabidopsis Cotyledons for Sequential Analysis of Phloem Differentiation.
    Methods in molecular biology, 1830, 149-159.
  • Kondo, Y., Suguchi, S. and Fukuda, H. (2017)
    Easy and Rapid Induction of Vascular Cells by VISUAL.
    CYTOLOGIA, 82, 335.
  • Saito, M., Nurani, A.M., Kondo, Y. and Fukuda, H. (2017)
    Tissue Culture for Xylem Differentiation with Arabidopsis Leaves.
    Methods in molecular biology, 1544, 59-65.
  • Kondo, Y. and Fukuda, H. (2015)
    The TDIF signaling network.
    Current opinion in plant biology, 28, 106-110.

連絡先

建物・部屋番号: 理学部C棟513号室(オフィス)、401号室(実験室)

電話: 078-803-5724

ファックス: 078-803-5724

E-mail: pkondo@tiger.kobe-u.ac.jp

URL: https://019.rakusaba.jp/~kondolab/